• DRAMP ID

    • DRAMP02045
    • Peptide Name

    • Brevinin-1-OR6 (Frogs, amphibians, animals)
    • Source

    • Odorrana rotodora (Chinese odorous frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • IIPFVAGVAAEMMEHVYCAASKKC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.1 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.2 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.2 µg/ml).
      • Yeast: Candida albicans (MIC=11.1 µg/ml).
    • Hemolytic Activity

      • [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys18 and Cys24)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys18 and Cys24.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02045 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C114H182N28O31S4
    • Absent Amino Acids

    • DLNQRTW
    • Common Amino Acids

    • A
    • Mass

    • 2569.11
    • PI

    • 6.74
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +1
    • Boman Index

    • 9.27
    • Hydrophobicity

    • 0.838
    • Aliphatic Index

    • 89.58
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 70.22
    • Polar Residues

    • 5

DRAMP02045

DRAMP02045 chydropathy plot
    • It differs from AP1827 at two positions

    • 2
  • ·Literature 1
    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.
    • Author

    • Yang X, Lee WH, Zhang Y.