• • DRAMP ID

  • DRAMP02059

• • Peptide Name

  • Brevinin-2-OA6 (Frogs, amphibians, animals)

• • Source

  • Odorrana andersonii (Chinese odorous frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC

• • Sequence Length

  • 33

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 µg/ml);
    • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 µg/ml).
    • Yeast: Candida albicans (MIC=11.2 µg/ml).

• • Hemolytic Activity

  • • [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys27 and Cys33)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys27 and Cys33.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP02059_predicted_structure.pdb to download.

DRAMP02059

• • Function

  • Has antibacterial and antifungal activity.

• ·Literature 1

• • Title

  • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

• • Pubmed ID

  • 22029824

• • Reference

  • J Proteome Res. 2012 Jan 1;11(1):306-319.

• • Author

  • Yang X, Lee WH, Zhang Y.