• • DRAMP ID

  • DRAMP02075

• • Peptide Name

  • Brevinin-1JDc (Frogs, amphibians, animals)

• • Source

  • Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FLPAVLRVAAKVVPTVFCLISKKC

• • Sequence Length

  • 24

• • UniProt Entry

  • B3A0N0

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), S. aureus (MRSA) (MIC=8 µg/ml);
    • Gram-negative bacterium: Escherichia coli (MIC=128 µg/ml).

• • Hemolytic Activity

  • • [Ref.22917879] It has 11.7 ± 3.2% hemolytic activity at 64 μg/mL and 88.4 ± 4.2% hemolytic activity at 128 μg/mL against rabbit red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys18 and Cys24)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys18 and Cys24.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP02075_predicted_structure.pdb to download.

DRAMP02075

• • Function

  • Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes.

• • Tissue specificity

  • Expressed by the skin glands.

• • PTM

  • contains one disulfide bonds.

• ·Literature 1

• • Title

  • Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data.

• • Pubmed ID

  • 22917879

• • Reference

  • J Proteomics. 2012 Oct 22;75(18):5807-5821.

• • Author

  • Liu J, Jiang J, Wu Z, Xie F.