General Information

    • DRAMP ID

    • DRAMP02128

    • Peptide Name

    • Kassorin-S (PreproKassorin-S; Frogs, amphibians, animals)

    • Source

    • Kassina senegalensis (Senegal running frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLGGILNTITGLL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=30 µM).
      • Yeast: Candida albicans (MIC=100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02128 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02128.

Physicochemical Information

    • Formula

    • C63H106N14O17

    • Absent Amino Acids

    • ACDEHKMPQRSVWY

    • Common Amino Acids

    • L

    • Mass

    • 1331.62

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • 0

    • Boman Index

    • 23.54

    • Hydrophobicity

    • 1.608

    • Aliphatic Index

    • 180

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP02128

Comments Information

    • Function

    • Antimicrobial peptide. Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Lacks ability to induce contraction of smooth muscle in isolated guinea pig urinary bladder. Elicits histamine release from rat peritoneal mast cells.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Kassorins: novel innate immune system peptides from skin secretions of the African hyperoliid frogs, Kassina maculata and Kassina senegalensis.

    • Reference

    • Mol Immunol. 2011 Jan;48(4):442-451.

    • Author

    • Chen H, Wang L, Zeller M, Hornshaw M, Wu Y, Zhou M, Li J, Hang X, Cai J, Chen T, Shaw C.