General Information

    • DRAMP ID

    • DRAMP02187

    • Peptide Name

    • Ranatuerin-2AVa (Frogs, amphibians, animals)

    • Source

    • Rana arvalis (Moor frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLLDVVKGAAKNLLASALDKLKCKVTGC

    • Sequence Length

    • 28

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium:
        Target OrganismActivity
        L. lactis-

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02187 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02187.

Physicochemical Information

    • Formula

    • C124H222N34O36S2

    • Absent Amino Acids

    • EFHIMPQRWY

    • Common Amino Acids

    • L

    • Mass

    • 2829.45

    • PI

    • 9.24

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • -3.54

    • Hydrophobicity

    • 0.532

    • Aliphatic Index

    • 128.93

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.63

    • Polar Residues

    • 8

DRAMP02187

DRAMP02187 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacterium L. lactis.

    • PTM

    • Contains one disulfide bond 23-28.

Literature Information

  • ·Literature 1

    • Title

    • Mass spectrometric study of peptides secreted by the skin glands of the brown frog Rana arvalis from the Moscow region.

    • Reference

    • Rapid Commun Mass Spectrom. 2009 May;23(9):1241-1248.

    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.