• DRAMP ID

    • DRAMP02222
    • Peptide Name

    • Ranatuerin-2PLc (Frogs, amphibians, animals)
    • Source

    • Rana palustris (North America pickerel frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GLLDTIKNTAKNLAVGLLDKIKCKMTGC
    • Sequence Length

    • 28
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=3 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02222 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C128H229N35O38S3
    • Absent Amino Acids

    • EFHPQRSWY
    • Common Amino Acids

    • KL
    • Mass

    • 2962.62
    • PI

    • 9.24
    • Basic Residues

    • 5
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +3
    • Boman Index

    • -16.35
    • Hydrophobicity

    • 0.211
    • Aliphatic Index

    • 115
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.63
    • Polar Residues

    • 10

DRAMP02222

DRAMP02222 chydropathy plot
    • Function

    • May have antimicrobial activity against the Gram-negative bacterium E. coli.
    • Tissue specificity

    • Expressed by the skin glands.
  • ·Literature 1
    • Title

    • Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris.
    • Reference

    • Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.
    • Author

    • Basir YJ, Knoop FC, Dulka J, Conlon JM.