General Information

    • DRAMP ID

    • DRAMP02233

    • Peptide Name

    • Ranatuerin-6 (Frogs, amphibians, animals)

    • Source

    • Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FISAIASMLGKFL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antiviral

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02233 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02233.

Physicochemical Information

    • Formula

    • C67H108N14O16S

    • Absent Amino Acids

    • CDEHNPQRTVWY

    • Common Amino Acids

    • AFILS

    • Mass

    • 1397.74

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 20.2

    • Hydrophobicity

    • 1.677

    • Aliphatic Index

    • 135.38

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02233

Comments Information

    • This peptide could inhibit HIV infection <10% at a concentration that is also toxic to T cells (J Virol 2005; 79

    • 11598-11606).

Literature Information

  • ·Literature 1

    • Title

    • Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana.

    • Reference

    • Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.

    • Author

    • Goraya J, Knoop FC, Conlon JM.