General Information

    • DRAMP ID

    • DRAMP02241

    • Peptide Name

    • Ranatuerin-2G (Frogs, amphibians, animals)

    • Source

    • Rana grylio (North American pig frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLLLDTLKGAAKDIAGIALEKLKCKITGCKP

    • Sequence Length

    • 31

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=19 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=150 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02241 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C142H253N37O40S2

    • Absent Amino Acids

    • FHMNQRSVWY

    • Common Amino Acids

    • KL

    • Mass

    • 3182.91

    • PI

    • 9.19

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • -4.85

    • Hydrophobicity

    • 0.323

    • Aliphatic Index

    • 126.13

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.17

    • Polar Residues

    • 8

DRAMP02241

DRAMP02241 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio.

    • Reference

    • Regul Pept. 2000 Jun 30;90(1-3):53-60.

    • Author

    • Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM.