General Information
-
DRAMP ID
- DRAMP02256
-
Peptide Name
- Ranatuerin-2B (Ranatuerin 2B, Frog, amphibians, animals)
-
Source
- Rana berlandieri (Rio Grande leopard frog) (Rana luteiventris)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GLLDTIKGVAKTVAASMLDKLKCKISGC
-
Sequence Length
- 28
-
UniProt Entry
- P82840
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=2 µM);
- Gram-negative bacterium: Escherichia coli (MIC=2 µM);
- Yeast: Candida albicans (MIC=35 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP02256_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C124H223N33O37S3
Absent Amino Acids
- EFHNPQRWY
Common Amino Acids
- K
Mass
- 2864.51
PI
- 9.24
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- -6.37
Hydrophobicity
- 0.507
Aliphatic Index
- 115
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.63
Polar Residues
- 9
DRAMP02256
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
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Pubmed ID
- 10651828
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Reference
- Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
- Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.