• DRAMP ID

    • DRAMP02278
    • Peptide Name

    • Ranacyclin-B-RL1 (Frogs, amphibians, animals)
    • Source

    • Odorrana livida (Ranidae frogs)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • AALRGCWTKSIPPKPCPGKR
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=5.8 µM), Bacillus subtilis (MIC=46.2 µM);
      • Gram-negative bacterium: Escherichia coli.
      • Yeast: Candida albicans.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys6 and Cys16.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02278 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02278.
    • Formula

    • C96H160N30O23S2
    • Absent Amino Acids

    • DEFHMNQVY
    • Common Amino Acids

    • P
    • Mass

    • 2166.63
    • PI

    • 10.33
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Net Charge

    • +5
    • Boman Index

    • -32.23
    • Hydrophobicity

    • -0.67
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 296.05
    • Polar Residues

    • 6

DRAMP02278

DRAMP02278 chydropathy plot
    • Comment

    • No comments found on DRAMP database
  • ·Literature 1
    • Title

    • Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.
    • Reference

    • Amino Acids. 2012 Jul;43(1):309-316.
    • Author

    • Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R.