General Information
-
DRAMP ID
- DRAMP02379
-
Peptide Name
- Grammistin Gs B (Group II grammistin; soapfish, chordates, animals)
-
Source
- Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)
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Family
- Belongs to the grammistin family (Group 2 subfamily)
-
Gene
- Not found
-
Sequence
- IGGIISFFKRLF
-
Sequence Length
- 12
-
UniProt Entry
- P69839
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 µg/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 µg/ml);
- Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 µg/ml), Escherichia coli JCM 1649 (MIC=12.5 µg/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 µg/ml), Salmonella typhimurium S1 (MIC=12.5 µg/ml), S. putrefaciens IAM 1509 (MIC=3.13 µg/ml), Vibrio anguillarum NCIBM 829 (MIC=6.25 µg/ml), Vibrio parahaemolyticus (MIC=12.5 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP02379_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C70H108N16O14
Absent Amino Acids
- ACDEHMNPQTVWY
Common Amino Acids
- FI
Mass
- 1397.73
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +2
-
Boman Index
- 6.63
Hydrophobicity
- 1.308
Aliphatic Index
- 130
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP02379
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus.
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Pubmed ID
- 15777955
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Reference
- Toxicon. 2005 Apr;45(5):595-601.
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Author
- Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K.