General Information

    • DRAMP ID

    • DRAMP02386

    • Peptide Name

    • Parasin I (histone-H2A-derived; catfishes, chordates, animals)

    • Source

    • Parasilurus asotus (Amur catfish)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KGRGKQGGKVRAKAKTRSS

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Aeromonas salmonicida (MIC=10 µg/ml), Cytophaga aquatilis (MIC=5 µg/ml), Yersinia rukeri (MIC=15 µg/ml), Edwardsiella ictaluri (MIC=10 µg/ml), Lactococcus garvieae (MIC=10 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02386 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02386.

Physicochemical Information

    • Formula

    • C82H154N34O24

    • Absent Amino Acids

    • CDEFHILMNPWY

    • Common Amino Acids

    • K

    • Mass

    • 2000.34

    • PI

    • 12.32

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +8

    • Boman Index

    • -76

    • Hydrophobicity

    • -1.716

    • Aliphatic Index

    • 25.79

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP02386

DRAMP02386 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Parasin I, an antimicrobial peptide derived from histon H2A in the catfish, Parasilurus asotus.

    • Reference

    • FEBS Lett 1998; 437: 258-262.

    • Author

    • Park IY, Park CB, Kim MS, Kim SC.