General Information

    • DRAMP ID

    • DRAMP02396

    • Peptide Name

    • OEP3121 (EP5-1;earthworm,animals)

    • Source

    • Eisenia foetida (Common brandling worm) (Common dung-worm)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ACSAG

    • Sequence Length

    • 5

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02396 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02396.

Physicochemical Information

    • Formula

    • C14H25N5O7S

    • Absent Amino Acids

    • DEFHIKLMNPQRTVWY

    • Common Amino Acids

    • A

    • Mass

    • 407.44

    • PI

    • 5.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • 2.44

    • Hydrophobicity

    • 0.98

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP02396

Comments Information

    • Function

    • Displays antimicrobial activity. The effects of EP5 on HeLa cells lead to the cancer cell's apoptosis and break down.

Literature Information

  • ·Literature 1

    • Title

    • Purification of a novel antibacterial short peptide in earthworm Eisenia foetida.

    • Reference

    • Acta Biochim Biophys Sin (Shanghai). 2004 Apr;36(4):297-302.

    • Author

    • Liu YQ, Sun ZJ, Wang C, Li SJ, Liu YZ.
  • ·Literature 2

    • Title

    • A novel antimicrobial vermipeptide family from earthworm Eisenia fetida.

    • Reference

    • European Journal of Soil Biology, 2007, 43:S127-S134.

    • Author

    • C Wang, Z Suna, X Zhang, G Xu.