General Information

    • DRAMP ID

    • DRAMP02402

    • Peptide Name

    • Antimicrobial peptide scolopin-1

    • Source

    • Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPKMSTKLRVPYRRGTKDYH

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 µg/ml), E. coli drug-resistant strain (MIC=15 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 µg/ml), S. aureus drug-resistant strain (MIC=5.0 µg/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 µg/ml);
      • Yeast: Candida albicans (MIC=15 µg/ml).

    • Hemolytic Activity

      • [Ref.19716842]25 ± 2% hemolytic activity at 50 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02402 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C118H189N35O29S

    • Absent Amino Acids

    • ACEINQW

    • Common Amino Acids

    • KR

    • Mass

    • 2594.08

    • PI

    • 10.55

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -63.46

    • Hydrophobicity

    • -1.133

    • Aliphatic Index

    • 50.95

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 149

    • Polar Residues

    • 6

DRAMP02402

DRAMP02402 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide against both Gram-positive, Gram-positive and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Two novel antimicrobial peptides from centipede venoms.

    • Reference

    • Toxicon. 2010 Feb-Mar;55(2-3):274-279.

    • Author

    • Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H.