General Information

    • DRAMP ID

    • DRAMP02403

    • Peptide Name

    • Antimicrobial peptide scolopin-2

    • Source

    • Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GILKKFMLHRGTKVYKMRTLSKRSH

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 µg/ml), S. aureus drug-resistant strain (MIC=1.0 µg/ml), Bacillus dysenteriae standard strain (MIC=2.5 µg/ml), B. dysenteriae drug-resistant strain (MIC=5.0 µg/ml);
      • Yeast: Candida albicans (MIC=7.5 µg/ml).

    • Hemolytic Activity

      • [Ref.19716842]32 ± 7% hemolytic activity at 50 μg/ml against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02403 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02403.

Physicochemical Information

    • Formula

    • C135H231N43O31S2

    • Absent Amino Acids

    • ACDENPQW

    • Common Amino Acids

    • K

    • Mass

    • 3016.71

    • PI

    • 11.76

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +10

    • Boman Index

    • -60.63

    • Hydrophobicity

    • -0.712

    • Aliphatic Index

    • 74

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 62.08

    • Polar Residues

    • 7

DRAMP02403

DRAMP02403 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide against both Gram-positive, -negative and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Two novel antimicrobial peptides from centipede venoms.

    • Reference

    • Toxicon. 2010 Feb-Mar;55(2-3):274-279.

    • Author

    • Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H.