General Information

    • DRAMP ID

    • DRAMP02430

    • Peptide Name

    • Ixosin (Ticks, Arthropods, animals)

    • Source

    • Ixodes sinensis (Hard tick)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLHKVMREVLGYERNSYKKFFLR

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=30 µg/ml);
      • Fungi: Candida albicans (MIC=7.5 µg/ml).

    • Hemolytic Activity

      • [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 μg/mL

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02430 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C132H208N38O32S

    • Absent Amino Acids

    • ACDIPQTW

    • Common Amino Acids

    • KLR

    • Mass

    • 2871.4

    • PI

    • 10.16

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +5

    • Boman Index

    • -56.98

    • Hydrophobicity

    • -0.687

    • Aliphatic Index

    • 76.09

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 6

DRAMP02430

DRAMP02430 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis.

    • Reference

    • Peptides. 2006 Jan;27(1):31-5.

    • Author

    • Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R.