• DRAMP ID

    • DRAMP02430
    • Peptide Name

    • Ixosin (Ticks, Arthropods, animals)
    • Source

    • Ixodes sinensis (Hard tick)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLHKVMREVLGYERNSYKKFFLR
    • Sequence Length

    • 23
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=30 µg/ml);
      • Fungi: Candida albicans (MIC=7.5 µg/ml).
    • Hemolytic Activity

      • [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 μg/mL
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02430 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02430.
    • Formula

    • C132H208N38O32S
    • Absent Amino Acids

    • ACDIPQTW
    • Common Amino Acids

    • KLR
    • Mass

    • 2871.4
    • PI

    • 10.16
    • Basic Residues

    • 7
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 7
    • Net Charge

    • +5
    • Boman Index

    • -56.98
    • Hydrophobicity

    • -0.687
    • Aliphatic Index

    • 76.09
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 2980
    • Absorbance 280nm

    • 135.45
    • Polar Residues

    • 6

DRAMP02430

DRAMP02430 chydropathy plot
    • Function

    • Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes.
  • ·Literature 1
    • Title

    • A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis.
    • Reference

    • Peptides. 2006 Jan;27(1):31-5.
    • Author

    • Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R.