General Information

    • DRAMP ID

    • DRAMP02488

    • Peptide Name

    • L-amino-acid oxidase ACTX-8 (LAAO; LAO; Snakes, reptiles, animals)

    • Source

    • Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus)

    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)

    • Gene

    • Not found

    • Sequence

    • ADDRNPLEEFRENNYEEFL

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antitumor, Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02488 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02488.

Physicochemical Information

    • Formula

    • C104H150N28O38

    • Absent Amino Acids

    • CGHIKMQSTVW

    • Common Amino Acids

    • E

    • Mass

    • 2400.5

    • PI

    • 4

    • Basic Residues

    • 2

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -5

    • Boman Index

    • -83.78

    • Hydrophobicity

    • -1.679

    • Aliphatic Index

    • 46.32

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 82.78

    • Polar Residues

    • 4

DRAMP02488

DRAMP02488 chydropathy plot

Comments Information

    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). Induces apoptosis in HeLa cervical cancer cells. Both the caspase-dependent and the mitochondrial pathways seem to be involved in apoptosis.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells.

    • Reference

    • Life Sci. 2007 Mar 6;80(13):1189-1197.

    • Author

    • Zhang L, Wei LJ.