General Information
-
DRAMP ID
- DRAMP02751
-
Peptide Name
- Formaecin-1 (Pro-rich; ants, insects, animals)
-
Source
- Myrmecia gulosa (Red bulldog ant)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GRPNPVNNKPTPHPRL
-
Sequence Length
- 16
-
UniProt Entry
- P81438
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Ref.9497332] Gram-negative bacteria: Escherichia coli NCTC 8196, Escherichia coli BLR.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Rich
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02751.
Physicochemical Information
-
Formula
- C78H128N28O21
Absent Amino Acids
- ACDEFIMQSWY
Common Amino Acids
- P
Mass
- 1794.05
PI
- 12.01
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- +4
-
Boman Index
- -52.64
Hydrophobicity
- -1.731
Aliphatic Index
- 42.5
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP02751
Comments Information
Function
- Antibacterial activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.
Induction
- By bacterial infection.
PTM
- O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.
Literature Information
- ·Literature 1
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Title
- Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides.
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Pubmed ID
- 9497332
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Reference
- J Biol Chem. 1998 Mar 13;273(11):6139-6143.
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Author
- Mackintosh JA, Veal DA, Beattie AJ, Gooley AA.