• • DRAMP ID

  • DRAMP02854

• • Peptide Name

  • Cathelicidin-5 (Antibacterial peptide BMAP-28; Myeloid antib

• • Source

  • Bos taurus (Bovine)

• • Family

  • Belongs to the cathelicidin family

• • Gene

  • CATHL5

• • Sequence

  • GGLRSLGRKILRAWKKYGPIIVPIIRIG

• • Sequence Length

  • 28

• • UniProt Entry

  • P54229,A5PJ96,B9UKL6

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 µM), E. coli ML35 (MIC=2 µM), E. coli D21 (MIC=0.5 µM), Salmonella typhimurium ATCC 14028 (MIC=1 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=1 µM), Serratia marcescens ATCC 8100 (MIC=2 µM);
    • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 µM), Staphylococcus aureus Cowan 1 (MIC=1 µM), Staphylococcus aureus (MRSA) (MIC=4 µM), Staphylococcus epidermidis ATCC 12228 (MIC=1 µM), Bacillus megaterium Bm11 (MIC=2 µM).
    • Fungi: Candida albicans (MIC=8 µM), Cryptococcus neoformans (MIC=4 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 2NDC

• Predicted Structure

• Please click DRAMP02854_predicted_structure.pdb to download.

DRAMP02854

• • Function

  • Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.

• • PTM

  • Contains two disulfide bonds. (By similarity)

• ·Literature 1

• • Title

  • Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.

• • Pubmed ID

  • 8910461

• • Reference

  • J Biol Chem. 1996 Nov 8;271(45):28375-28381.

• • Author

  • Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.

• ·Literature 2

• • Title

  • Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.

• • Pubmed ID

  • 8706679

• • Reference

  • Eur J Biochem. 1996 Jun 15;238(3):769-776.

• • Author

  • Storici P, Tossi A, Lenarcic B, Romeo D.