• DRAMP ID

    • DRAMP02869
    • Peptide Name

    • Bovine Beta-defensin 12 (bBD-12; BNBD-12; BNDB-12; mammals, animals)
    • Source

    • Bos taurus (Bovine)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • DEFB12
    • Sequence

    • GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW
    • Sequence Length

    • 38
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 µg/ml);
      • Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Beta strand
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02869 helical wheel diagram
    • PDB ID

    • 1BNB resolved by NMR.
  • 1BNB-> 
    • Predicted Structure

    • There is no predicted structure for DRAMP02869.
    • Formula

    • C174H287N57O44S7
    • Absent Amino Acids

    • ADEHY
    • Common Amino Acids

    • CG
    • Mass

    • 4105.97
    • PI

    • 9.57
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +6
    • Boman Index

    • -48.92
    • Hydrophobicity

    • 0.068
    • Aliphatic Index

    • 63.95
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5875
    • Absorbance 280nm

    • 158.78
    • Polar Residues

    • 16

DRAMP02869

DRAMP02869 chydropathy plot
    • Function

    • Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
    • Tissue specificity

    • Neutrophilic granules.
    • PTM

    • Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)
  • ·Literature 1
    • Title

    • Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.
    • Reference

    • J Biol Chem. 1993 Mar 25;268(9):6641-6648.
    • Author

    • Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.
  • ·Literature 2
    • Title

    • Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils.
    • Reference

    • J Biol Chem. 1993 Mar 25;268(9):6649-6653.
    • Author

    • Tang YQ, Selsted ME.