• DRAMP ID

    • DRAMP02874
    • Peptide Name

    • Chromacin (mammals, animals)
    • Source

    • Bos taurus (Bovine)
    • Family

    • Belongs to the chromogranin/secretogranin protein family
    • Gene

    • CHGA
    • Sequence

    • YPGPQAKEDSEGPSQGPASREK
    • Sequence Length

    • 22
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Binds calcium with a low-affinity.
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02874 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02874.
    • Formula

    • C97H151N29O37
    • Absent Amino Acids

    • CFHILMNTVW
    • Common Amino Acids

    • P
    • Mass

    • 2315.44
    • PI

    • 4.87
    • Basic Residues

    • 3
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 2
    • Net Charge

    • -1
    • Boman Index

    • -70.15
    • Hydrophobicity

    • -1.864
    • Aliphatic Index

    • 9.09
    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 70.95
    • Polar Residues

    • 7

DRAMP02874

DRAMP02874 chydropathy plot
    • Function

    • Has antibacterial activity against the Gram-positive bacterium M. luteus.
  • ·Literature 1
    • Title

    • Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules.
    • Reference

    • J Biol Chem. 1996 Nov 8;271(45):28533-28540.
    • Author

    • Strub JM, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, van Dorsselaer A, Aunis D, Metz-Boutigue MH.