General Information

    • DRAMP ID

    • DRAMP02876

    • Peptide Name

    • Alpha-melanocyte-stimulating hormone (Alpha-MSH; mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the POMC family

    • Gene

    • POMC

    • Sequence

    • SYSMEHFRWGKPV

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • The last three residues KPV are antimicrobial.

    • Helical Wheel Diagram

    • DRAMP02876 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02876.

Physicochemical Information

    • Formula

    • C75H106N20O19S

    • Absent Amino Acids

    • ACDILNQT

    • Common Amino Acids

    • S

    • Mass

    • 1623.85

    • PI

    • 8.33

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -26.24

    • Hydrophobicity

    • -0.923

    • Aliphatic Index

    • 22.31

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 582.5

    • Polar Residues

    • 4

DRAMP02876

Comments Information

    • Function

    • Has antibacterial activity against Gram-positive bacterium S. aureus. Also has antifungl activity against yeast C. albicans.

    • Miscellaneous

    • Alpha-MSH has potent anti-inflammatory influences in models of acute, chronic, and systemic inflammation. Its wide spectrum of activity and low toxicity suggest that a-MSH may be useful for treatment of inflammation in human and veterinary disorders.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effects of alpha-MSH peptides.

    • Reference

    • J Leukoc Biol 2000; 67(2): 233-239.

    • Author

    • Cutuli M, Cristiani S, Lipton JM, Catania A.