General Information

    • DRAMP ID

    • DRAMP03011

    • Peptide Name

    • Bombolitin IV (insects, arthropods, invertebrates, animals)

    • Source

    • Megabombus pennsylvanicus (Bumblebee)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INIKDILAKLVKVLGHV

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti Mammalian Cells

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.2578459] Hemolysis: ED50=1.8±0.05 µg/ml. Histamine release: ED50=12.5±0.7 µg/ml against guinea pig erythrocytes.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03011 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03011.

Physicochemical Information

    • Formula

    • C88H157N23O21

    • Absent Amino Acids

    • CEFMPQRSTWY

    • Common Amino Acids

    • IKLV

    • Mass

    • 1873.36

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 7.72

    • Hydrophobicity

    • 1

    • Aliphatic Index

    • 194.71

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP03011

Comments Information

    • Function

    • Mast cell degranulating peptide. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.

    • Reference

    • J Biol Chem. 1985 Feb 10;260(3):1437-144.

    • Author

    • Argiolas A, Pisano JJ.