• • DRAMP ID

  • DRAMP03039

• • Peptide Name

  • Eumenitin-F (Insects, animals)

• • Source

  • Eumenes fraterculus (Solitary wasp)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • LNLKGLFKKVASLLT

• • Sequence Length

  • 15

• • UniProt Entry

  • P0CJ37

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>60 µM), Staphylococcus epidermidis (clinical sample) (MIC=30 µM), Micrococcus luteus ATCC 10240 (MIC=30 µM), Streptococcus pyogenes (clinical sample) (MIC=30 µM), Bacillus subtilis ATCC 6633 (MIC=30 µM);
    • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 µM), Proteus mirabilis (clinical sample) (MIC>60 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=30 µM), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 µM);
    • Fungi: Candida albicans ATCC 90112 (MIC=7.5 µM).

• • Hemolytic Activity

  • • [Ref.21549739]EC50=353.4 μM against mice erythrocytes

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP03039_predicted_structure.pdb to download.

DRAMP03039

• • Function

  • Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes.

• • Tissue specificity

  • Expressed by the venom sac.

• ·Literature 1

• • Title

  • Chemical and biological characterization of four new linear cationic α-helical peptides from the venoms of two solitary eumenine wasps.

• • Pubmed ID

  • 21549739

• • Reference

  • Toxicon. 2011 Jun;57(7-8):1081-1092.

• • Author

  • Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K.