General Information

    • DRAMP ID

    • DRAMP03049

    • Peptide Name

    • Eumenine mastoparan-OD (EMP-OD; Venom peptide 1, OdVP1; Insects, animals)

    • Source

    • Orancistrocerus drewseni (Solitary wasp)

    • Family

    • Belongs to the MCD family (Mastoparan subfamily)

    • Gene

    • VP1

    • Sequence

    • GRILSFIKGLAEHL

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19857508]Fungi: Candida albicans, Botrytis cinerea (++);
      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacterium: S. aureus (+)

    • Hemolytic Activity

      • [Ref.18695936]42% hemolytic activity at 50 μM against sheep blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03049 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03049.

Physicochemical Information

    • Formula

    • C72H120N20O18

    • Absent Amino Acids

    • CDMNPQTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1553.87

    • PI

    • 8.75

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • -4.07

    • Hydrophobicity

    • 0.593

    • Aliphatic Index

    • 146.43

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03049

Comments Information

    • Function

    • Has hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation (Leucine amide

Literature Information

  • ·Literature 1

    • Title

    • Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).

    • Reference

    • Toxicon. 2010 Apr 1;55(4):711-718.

    • Author

    • Baek JH, Lee SH.
  • ·Literature 2

    • Title

    • Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni.

    • Reference

    • Amino Acids. 2009 Jul;37(2):389-394.

    • Author

    • Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T.