General Information

    • DRAMP ID

    • DRAMP03062

    • Peptide Name

    • Defensin-A (DefA; GmDefA; Insects, animals)

    • Source

    • Glossina morsitans morsitans (Savannah tsetse fly)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamily)

    • Gene

    • Not found

    • Sequence

    • VTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antiprotozoal

    • Target Organism

      • Protozoan: Procyclic trypanosomes (IC50=10 µM).
      • Gram-negative bacteria: Sodalis (IC50=2 µM)，Escherichia coli DH5α (IC50=0.2 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03062 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03062.

Physicochemical Information

    • Formula

    • C199H325N63O62S6

    • Absent Amino Acids

    • FMPQ

    • Common Amino Acids

    • C

    • Mass

    • 4784.51

    • PI

    • 9.08

    • Basic Residues

    • 9

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +6

    • Boman Index

    • -95.4

    • Hydrophobicity

    • -0.5

    • Aliphatic Index

    • 54.19

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8855

    • Absorbance 280nm

    • 210.83

    • Polar Residues

    • 22

DRAMP03062

DRAMP03062 chydropathy plot

Comments Information

    • Function

    • Antibacterial peptide mostly active against Gram-positive and Gram-negative bacteria.

    • Tissue specificity

    • Hemolymph and fat body.

    • Induction

    • By bacterial infection.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis.

    • Reference

    • Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12648-12653.

    • Author

    • Hao Z, Kasumba I, Lehane MJ, Gibson WC, Kwon J, Aksoy S.
  • ·Literature 2

    • Title

    • Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections.

    • Reference

    • Insect Biochem Mol Biol. 2002 Apr;32(4):369-375.

    • Author

    • Boulanger N, Brun R, Ehret-Sabatier L, Kunz C, Bulet P.