General Information

    • DRAMP ID

    • DRAMP03074

    • Peptide Name

    • Cecropin (Insects, animals)

    • Source

    • Glossina morsitans morsitans (Savannah tsetse fly)

    • Family

    • Belongs to the cecropin family

    • Gene

    • Not found

    • Sequence

    • GWLKKIGKKIERVGQNTRDATVKGLEVAQQAANVAATVR

    • Sequence Length

    • 39

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03074 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03074.

Physicochemical Information

    • Formula

    • C183H315N59O54

    • Absent Amino Acids

    • CFHMPSY

    • Common Amino Acids

    • A

    • Mass

    • 4205.88

    • PI

    • 10.55

    • Basic Residues

    • 8

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +5

    • Boman Index

    • -75.63

    • Hydrophobicity

    • -0.441

    • Aliphatic Index

    • 92.56

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 144.74

    • Polar Residues

    • 9

DRAMP03074

DRAMP03074 chydropathy plot

Comments Information

    • Function

    • Cecropins have lytic and antibacterial activity against several Gram-negative bacteria.

    • Tissue specificity

    • Hemolymph.

    • Induction

    • By bacterial and parasitic infection.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections.

    • Reference

    • Insect Biochem. Mol. Biol. 2002; 32:369-375.

    • Author

    • Boulanger N, Brun R, Ehret-Sabatier L, Kunz C, Bulet P.