General Information

    • DRAMP ID

    • DRAMP03077

    • Peptide Name

    • Cecropin-2 (Cecropin 2; Md-Cec, Mdc; Insects, animals)

    • Source

    • Ceratitis capitata (Mediterranean fruit fly) (Musca domestica)

    • Family

    • Belongs to the cecropin family

    • Gene

    • CEC2

    • Sequence

    • GWLKKIGKKIERVGQHTRDATIQTIGVAQQAANVAATLK

    • Sequence Length

    • 39

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03077 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03077.

Physicochemical Information

    • Formula

    • C185H316N58O53

    • Absent Amino Acids

    • CFMPSY

    • Common Amino Acids

    • A

    • Mass

    • 4200.9

    • PI

    • 10.56

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +6

    • Boman Index

    • -58.27

    • Hydrophobicity

    • -0.321

    • Aliphatic Index

    • 97.69

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 144.74

    • Polar Residues

    • 9

DRAMP03077

DRAMP03077 chydropathy plot

Comments Information

    • Function

    • Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

    • PTM

    • C-terminal amidation (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Sequences of two cDNA clones from the medfly Ceratitis capitata encoding antibacterial peptides of the cecropin family.

    • Reference

    • Gene. 1993 Dec 8;134(2):241-243.

    • Author

    • Rosetto M, Manetti AG, Marchini D, Dallai R, Telford JL, Baldari CT.