General Information
-
DRAMP ID
- DRAMP03084
-
Peptide Name
- Ceratotoxin-B (Insects, animals)
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Source
- Ceratitis capitata (Mediterranean Fruit fly)
-
Family
- Not found
-
Gene
- CTXB
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Sequence
- SIGSAFKKALPVAKKIGKAALPIAKAALP
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Sequence Length
- 29
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UniProt Entry
- P36191
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
- [Swiss_Prot Entry P36191]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria
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Hemolytic Activity
-
- [Swiss_Prot Entry P36191]has hemolytic activity
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03084.
Physicochemical Information
-
Formula
- C135H235N35O32
Absent Amino Acids
- CDEHMNQRTWY
Common Amino Acids
- A
Mass
- 2860.57
PI
- 10.7
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 16
Net Charge
- +6
-
Boman Index
- 12.8
Hydrophobicity
- 0.541
Aliphatic Index
- 118.28
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP03084
Comments Information
Function
- Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. They have as well hemolytic activity.
Temperature dependence
- Thermostable. Still active at 100 degrees Celsius.
Literature Information
- ·Literature 1
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Title
- Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera).
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Pubmed ID
- 8353519
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Reference
- Insect Biochem Mol Biol. 1993 Jul;23(5):591-598.
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Author
- Marchini D, Giordano PC, Amons R, Bernini LF, Dallai R.