General Information

    • DRAMP ID

    • DRAMP03105

    • Peptide Name

    • Antifungal protein (AFP; Insects, animals)

    • Source

    • Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • QHGHGGQDQHGYGHGQQAVYGKGHEGHGVNNLGQDGHGQHGYAHGHSDQHGHGGQHGQHDGYKNRGY

    • Sequence Length

    • 67

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03105 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03105.

Physicochemical Information

    • Formula

    • C297H413N113O97

    • Absent Amino Acids

    • CFIMPTW

    • Common Amino Acids

    • G

    • Mass

    • 7118.24

    • PI

    • 6.73

    • Basic Residues

    • 17

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +12

    • Boman Index

    • -176.01

    • Hydrophobicity

    • -1.791

    • Aliphatic Index

    • 17.46

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7450

    • Absorbance 280nm

    • 112.88

    • Polar Residues

    • 30

DRAMP03105

DRAMP03105 chydropathy plot

Comments Information

    • Function

    • This protein inhibits the growth of a variety of fungal species. The antifungal activity of this protein is enhanced by the presence of sarcotoxin IA.

Literature Information

  • ·Literature 1

    • Title

    • Purification, characterization, and cDNA cloning of an antifungal protein from the hemolymph of Sarcophaga peregrina (flesh fly) larvae.

    • Reference

    • J Biol Chem. 1993 Jun 5;268(16):12055-12061.

    • Author

    • Iijima R, Kurata S, Natori S.
  • ·Literature 2

    • Title

    • Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.

    • Reference

    • J Biol Chem. 1993 Mar 25;268(9):6641-6648.

    • Author

    • Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.