General Information
-
DRAMP ID
- DRAMP03120
-
Peptide Name
- Def-BBB (hybrid defensins; Insects, animals)
-
Source
- Anopheles gambiae (African malaria mosquito)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ATCDLASFSSQWVTPNDSLCAAHCLVKGYRGGYCKNKICHCRDKF
-
Sequence Length
- 45
-
UniProt Entry
- Q17027
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus strain 21 (IC90=10 µg/mL), Staphylococcus aureus strain 4 (IC90>80 µg/mL).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Combine helix and strand structure
-
Structure Description
- Global fold has a N-terminal loop L1, followed by a helix and a two-stranded antiparallel β-sheet forming the CSab motif.
-
Helical Wheel Diagram
-
PDB ID
- 2E3E resolved by NMR.
-
Predicted Structure
- There is no predicted structure for DRAMP03120.
Physicochemical Information
-
Formula
- C215H331N63O63S6
Absent Amino Acids
- EM
Common Amino Acids
- C
Mass
- 4998.74
PI
- 8.64
Basic Residues
- 8
Acidic Residues
- 3
Hydrophobic Residues
- 13
Net Charge
- +5
-
Boman Index
- -71.57
Hydrophobicity
- -0.24
Aliphatic Index
- 56.44
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 201.25
Polar Residues
- 19
DRAMP03120
Comments Information
Function
- Responsible for the anti Gram-positive activity of immune hemolymph and proves to be efficient against sensitive
strains as against resistant and multi-resistant strains.
Literature Information
- ·Literature 1
-
Title
- Rational design of peptides active against the gram positive bacteria Staphylococcus aureus.
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Pubmed ID
- 18214975
-
Reference
- Proteins. 2008 Jul;72(1):229-239.
-
Author
- Landon C, Barbault F, Legrain M, Guenneugues M, Vovelle F.