General Information

    • DRAMP ID

    • DRAMP03156

    • Peptide Name

    • Cathelicidin-3 (Bactenecin-7, Bac7; PR-59; mammals, animals)

    • Source

    • Ovis aries (Sheep)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • CATHL3

    • Sequence

    • RRLRPRRPRLPRPRPRPRPRPRSLPLPRPQPRRIPRPILLPWRPPRPIPRPQPQPIPRWL

    • Sequence Length

    • 60

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03156 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03156.

Physicochemical Information

    • Formula

    • C341H573N125O65

    • Absent Amino Acids

    • ACDEFGHKMNTVY

    • Common Amino Acids

    • P

    • Mass

    • 7464.1

    • PI

    • 13.28

    • Basic Residues

    • 20

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +20

    • Boman Index

    • -259.64

    • Hydrophobicity

    • -1.588

    • Aliphatic Index

    • 71.5

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 186.44

    • Polar Residues

    • 1

DRAMP03156

DRAMP03156 chydropathy plot

Comments Information

    • Function

    • Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.

Literature Information

  • ·Literature 1

    • Title

    • cDNA sequences of three sheep myeloid cathelicidins.

    • Reference

    • FEBS Lett. 1995 Dec 4;376(3):225-228.

    • Author

    • Bagella L, Scocchi M, Zanetti M.