General Information

    • DRAMP ID

    • DRAMP03195

    • Peptide Name

    • Theta defensin subunit B (primates, mammals, animals)

    • Source

    • Papio hamadryas (Hamadryas baboon)

    • Family

    • Belongs to the alpha-defensin family (Theta subfamily)

    • Gene

    • Not found

    • Sequence

    • RCVCRRGVC

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03195 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03195.

Physicochemical Information

    • Formula

    • C39H74N18O10S3

    • Absent Amino Acids

    • ADEFHIKLMNPQSTWY

    • Common Amino Acids

    • CR

    • Mass

    • 1051.31

    • PI

    • 9.31

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +3

    • Boman Index

    • -31.9

    • Hydrophobicity

    • 0.222

    • Aliphatic Index

    • 64.44

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 15.63

    • Polar Residues

    • 4

DRAMP03195

Comments Information

    • Forms a cyclic peptide with subunit A (PhTD-1). An additional intersubunit disulfide bond is formed.

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.

    • Reference

    • Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.

    • Author

    • Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.