General Information

    • DRAMP ID

    • DRAMP03200

    • Peptide Name

    • PhD2 (PhD-2; Defensin-2; primates, mammals, animals)

    • Source

    • Papio hamadryas (Hamadryas baboon)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • RICRCRIGRCLGLEVYFGVCFLHGRLARRCCR

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03200 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03200.

Physicochemical Information

    • Formula

    • C161H270N58O36S6

    • Absent Amino Acids

    • DKMNPQSTW

    • Common Amino Acids

    • R

    • Mass

    • 3786.64

    • PI

    • 9.98

    • Basic Residues

    • 9

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +8

    • Boman Index

    • -74.16

    • Hydrophobicity

    • 0.294

    • Aliphatic Index

    • 94.38

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 60.16

    • Polar Residues

    • 11

DRAMP03200

DRAMP03200 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.

    • Reference

    • Biochemistry (Mosc). 2006 Aug;71(8):879-83.

    • Author

    • Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN.