General Information

    • DRAMP ID

    • DRAMP03211

    • Peptide Name

    • BTD-4 (theta-defensin; primates, mammals, animals)

    • Source

    • Papio anubis (Olive baboon)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RCVCTRGFCRCICLLGIC

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus 502a;
      • Gram-negative bacterium: Escherichia coli ML35.
      • Fungi: Candida albicans 16820.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03211 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03211.

Physicochemical Information

    • Formula

    • C82H143N27O20S6

    • Absent Amino Acids

    • ADEHKMNPQSWY

    • Common Amino Acids

    • C

    • Mass

    • 2019.57

    • PI

    • 8.72

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -11.07

    • Hydrophobicity

    • 1.311

    • Aliphatic Index

    • 102.78

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 22.06

    • Polar Residues

    • 9

DRAMP03211

DRAMP03211 chydropathy plot

Comments Information

    • Function

    • BTD-4 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820. Among the five BTD detected, BTD-4 is least positively charged (net charge +2). This may be responsible for its weaker antimicrobial activity observed in vitro. It disrupts E. coli membranes.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.

    • Reference

    • Infect Immun. 2008 Dec;76(12):5883-5891.

    • Author

    • Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME.