General Information

    • DRAMP ID

    • DRAMP03219

    • Peptide Name

    • M-oxotoxin-OtIIb (Oxyopinin-IIb, OxkiIIb; spiders, Arthropods, animals)

    • Source

    • Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)

    • Family

    • Belongs to the oxyopinin-2 family

    • Gene

    • Not found

    • Sequence

    • GKFSGFAKILKSIAKFFKGVGKVRKQFKEASDLDKNQ

    • Sequence Length

    • 37

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Insecticidal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.11976325]10% hemolytic activity at 50 µM against sheep red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03219 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03219.

Physicochemical Information

    • Formula

    • C192H310N52O50

    • Absent Amino Acids

    • CHMPTWY

    • Common Amino Acids

    • K

    • Mass

    • 4146.89

    • PI

    • 10.3

    • Basic Residues

    • 10

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +7

    • Boman Index

    • -65.19

    • Hydrophobicity

    • -0.546

    • Aliphatic Index

    • 65.95

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP03219

DRAMP03219 chydropathy plot

Comments Information

    • Function

    • Disrupts biological membranes, particularly those rich in phosphocholine. Has antimicrobial activity against Gram- negative bacterium E. coli and the Gram-positive bacteria B. subtilis and S. aureus, and hemolytic activity against sheep red blood cells. Has insecticidal activity against S. frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides.

Literature Information

  • ·Literature 1

    • Title

    • Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.

    • Reference

    • J Biol Chem. 2002 Jun 28;277(26):23627-23637.

    • Author

    • Corzo G, Villegas E, Gómez-Lagunas F, Possani LD, Belokoneva OS, Nakajima T.