General Information

    • DRAMP ID

    • DRAMP03228

    • Peptide Name

    • M-zodatoxin-Lt2b (M-ZDTX-Lt2b; Latarcin-2b, Ltc-2b; spiders, Arthropods, animals)

    • Source

    • Lachesana tarabaevi (Spider)

    • Family

    • Belongs to the latarcin family

    • Gene

    • Not found

    • Sequence

    • GLFGKLIKKFGRKAISYAVKKARGKN

    • Sequence Length

    • 26

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Swiss_Prot Entry Q1ELU0]has a strong hemolytic activity against rabbit erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03228 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03228.

Physicochemical Information

    • Formula

    • C134H228N40O30

    • Absent Amino Acids

    • CDEHMPQTW

    • Common Amino Acids

    • K

    • Mass

    • 2879.53

    • PI

    • 11.33

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +9

    • Boman Index

    • -40

    • Hydrophobicity

    • -0.45

    • Aliphatic Index

    • 82.69

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 59.6

    • Polar Residues

    • 7

DRAMP03228

DRAMP03228 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity against both Gram-positive and Gram-negative bacteria, and the yeasts. Also has a strong hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.

    • Reference

    • J Biol Chem. 2006 Jul 28;281(30):20983-209892.

    • Author

    • Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.