General Information

    • DRAMP ID

    • DRAMP03255

    • Peptide Name

    • M-lycotoxin-Ls4a (M-LCTX-Ls4a; Peptide 2340; spiders, Arthropods, animals)

    • Source

    • Lycosa singoriensis (Wolf spider) (Aranea singoriensis)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MIASHLAFEKLSKLGSKHTML

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03255 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03255.

Physicochemical Information

    • Formula

    • C105H176N28O28S2

    • Absent Amino Acids

    • CDNPQRVWY

    • Common Amino Acids

    • L

    • Mass

    • 2342.84

    • PI

    • 9.7

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -8.71

    • Hydrophobicity

    • 0.229

    • Aliphatic Index

    • 102.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03255

DRAMP03255 chydropathy plot

Comments Information

    • Function

    • May inhibit growth of bacteria.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.

    • Reference

    • J Mass Spectrom. 2004 Feb;39(2):193-201.

    • Author

    • Budnik B.A, Olsen J.V, Egorov T.A, Anisimova V.E, Galkina T.G, Musolyamov A.K, Grishin E.V, Zubarev R.A.