General Information
-
DRAMP ID
- DRAMP03299
-
Peptide Name
- Defensin-A2 (DefA2; OaDefA2; mammals, animals)
-
Source
- Ornithorhynchus anatinus (Duckbill platypus)
-
Family
- Belongs to the alpha-defensin family
-
Gene
- Not found
-
Sequence
- STITCYCRSRCRMLEKNSGTCRSSNCTYTLCC
-
Sequence Length
- 32
-
UniProt Entry
- P0C8A2
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03299.
Physicochemical Information
-
Formula
- C142H239N47O49S8
Absent Amino Acids
- ADFHPQVW
Common Amino Acids
- C
Mass
- 3645.23
PI
- 8.83
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -88.44
Hydrophobicity
- -0.356
Aliphatic Index
- 36.56
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 108.23
Polar Residues
- 22
DRAMP03299
Comments Information
Function
- Has antimicrobial activity (By similarity).
Tissue specificity
- Highly expressed in intestine, expressed at lower levels in spleen, and at very low levels in kidney and lung.
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Defensins and the convergent evolution of platypus and reptile venom genes.
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Pubmed ID
- 18463304
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Reference
- Genome Res. 2008 Jun;18(6):986-994.
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Author
- Whittington CM, Papenfuss AT, Bansal P, Torres AM, Wong ES, Deakin JE, Graves T, Alsop A, Schatzkamer K, Kremitzki C, Ponting CP, Temple-Smith P, Warren WC, Kuchel PW, Belov K.
- ·Literature 2
-
Title
- Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.
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Pubmed ID
- 18662710
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Reference
- Toxicon. 2008 Sep 15;52(4):559-565.
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Author
- Whittington CM, Papenfuss AT, Kuchel PW, Belov K.