General Information

    • DRAMP ID

    • DRAMP03310

    • Peptide Name

    • Crabrolin (Insects, animals)

    • Source

    • Vespa crabro (European hornet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPLILRKIVTAL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O)C(C)C)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti Mammalian cells

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.6206053] Hemolysis is 20% of total at 10µg/ml against guinea pig red blood cell.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Helix

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP03310.

Physicochemical Information

    • Formula

    • C74H129N17O15

    • Absent Amino Acids

    • CDEGHMNQSWY

    • Common Amino Acids

    • L

    • Mass

    • 1496.94

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 15.31

    • Hydrophobicity

    • 1.715

    • Aliphatic Index

    • 210

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03310

Comments Information

    • Function

    • Mast cell degranulating peptide. Induces the chemotaxis of neutrophils. Has antimicrobial and hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs.

    • Reference

    • J Pept Res. 1997 Aug;50(2):88-93.

    • Author

    • Krishnakumari V, Nagaraj R.
  • ·Literature 2

    • Title

    • Isolation and characterization of two new peptides, mastoparan C and crabrolin, from the venom of the European hornet, Vespa crabro.

    • Reference

    • J Biol Chem. 1984 Aug 25;259(16):10106-10111.

    • Author

    • Argiolas A, Pisano JJ.