General Information
-
DRAMP ID
- DRAMP03310
-
Peptide Name
- Crabrolin (Insects, animals)
-
Source
- Vespa crabro (European hornet)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FLPLILRKIVTAL
-
Sequence Length
- 13
-
UniProt Entry
- P01518
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti Mammalian cells
-
Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- [Ref.6206053] Hemolysis is 20% of total at 10µg/ml against guinea pig red blood cell.
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03310.
Physicochemical Information
-
Formula
- C74H129N17O15
Absent Amino Acids
- CDEGHMNQSWY
Common Amino Acids
- L
Mass
- 1496.94
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +2
-
Boman Index
- 15.31
Hydrophobicity
- 1.715
Aliphatic Index
- 210
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP03310
Comments Information
Function
- Mast cell degranulating peptide. Induces the chemotaxis of neutrophils. Has antimicrobial and hemolytic activity.
Literature Information
- ·Literature 1
-
Title
- Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs.
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Pubmed ID
- 9273892
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Reference
- J Pept Res. 1997 Aug;50(2):88-93.
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Author
- Krishnakumari V, Nagaraj R.
- ·Literature 2
-
Title
- Isolation and characterization of two new peptides, mastoparan C and crabrolin, from the venom of the European hornet, Vespa crabro.
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Pubmed ID
- 6206053
-
Reference
- J Biol Chem. 1984 Aug 25;259(16):10106-10111.
-
Author
- Argiolas A, Pisano JJ.