General Information

    • DRAMP ID

    • DRAMP03347

    • Peptide Name

    • Alpha-defensin cryptdin-22 (Defensin-related cryptdin-22; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa22

    • Sequence

    • SRDLICLCRKRRCNRGELFYGTCAGPFLRCCRRRR

    • Sequence Length

    • 35

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03347 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03347.

Physicochemical Information

    • Formula

    • C175H297N67O44S6

    • Absent Amino Acids

    • HMQVW

    • Common Amino Acids

    • R

    • Mass

    • 4236.07

    • PI

    • 10.69

    • Basic Residues

    • 11

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +9

    • Boman Index

    • -140.16

    • Hydrophobicity

    • -0.654

    • Aliphatic Index

    • 58.57

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 54.85

    • Polar Residues

    • 13

DRAMP03347

DRAMP03347 chydropathy plot

Comments Information

    • Function

    • May have microbicidal activities (By similarity).

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.

    • Reference

    • Physiol Genomics. 2004 Dec 15;20(1):1-11.

    • Author

    • Patil A, Hughes AL, Zhang G.