General Information

    • DRAMP ID

    • DRAMP03447

    • Peptide Name

    • Beta-defensin 37 (Rodents, mammals, animals)

    • Source

    • Rattus norvegicus (Rat)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Defb37

    • Sequence

    • MKISCFLLLVLSLSCFQINPFAVLDTRVCIEKRNTCHILQCPLFRDVVGTCFEGIGKCCHKYF

    • Sequence Length

    • 63

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03447 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03447.

Physicochemical Information

    • Formula

    • C325H516N84O83S9

    • Absent Amino Acids

    • W

    • Common Amino Acids

    • CL

    • Mass

    • 7216.73

    • PI

    • 8.49

    • Basic Residues

    • 9

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 25

    • Net Charge

    • +5

    • Boman Index

    • -30.49

    • Hydrophobicity

    • 0.646

    • Aliphatic Index

    • 105.08

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1990

    • Absorbance 280nm

    • 32.1

    • Polar Residues

    • 20

DRAMP03447

DRAMP03447 chydropathy plot

Comments Information

    • Function Has antibacterial activity (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.

    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.