General Information

    • DRAMP ID

    • DRAMP03478

    • Peptide Name

    • Ganodermin (Fungus)

    • Source

    • Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AGETHTVMINHAGRGAPKLVVGGKKLS

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Botrytis cinerea (IC50=15.2 µM), Fusarium oxysporum (IC50=12.4 µM), Physalospora piricola (IC50=18.1 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03478 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03478.

Physicochemical Information

    • Formula

    • C118H202N38O34S

    • Absent Amino Acids

    • CDFQWY

    • Common Amino Acids

    • G

    • Mass

    • 2729.2

    • PI

    • 10.29

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +5

    • Boman Index

    • -23.52

    • Hydrophobicity

    • -0.126

    • Aliphatic Index

    • 86.67

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 9

DRAMP03478

DRAMP03478 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity. Lacks hemagglutinating activity towards rabbit erythrocytes. Lacks deoxyribonuclease, ribonuclease and protease inhibitory activities.

Literature Information

  • ·Literature 1

    • Title

    • Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom Ganoderma lucidum

    • Reference

    • Peptides. 2006 Jan;27(1):27-30. Epub 2005 Jul 21.

    • Author

    • Wang H, Ng TB.