General Information
-
DRAMP ID
- DRAMP03479
-
Peptide Name
- Bactericidin B-2 (Cecropin-like peptide B-2; Insects, animals)
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Source
- Manduca sexta (Tobacco hornworm)
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Family
- Belongs to the cecropin family
-
Gene
- Not found
-
Sequence
- WNPFKELERAGQRVRDAVISAAPAVATVGQAAAIARG
-
Sequence Length
- 37
-
UniProt Entry
- P14662
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03479.
Physicochemical Information
-
Formula
- C169H276N54O49
Absent Amino Acids
- CHMY
Common Amino Acids
- A
Mass
- 3848.38
PI
- 10.67
Basic Residues
- 5
Acidic Residues
- 3
Hydrophobic Residues
- 19
Net Charge
- +2
-
Boman Index
- -54.11
Hydrophobicity
- 0.019
Aliphatic Index
- 90
Half Life
-
- Mammalian:2.8 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 152.78
Polar Residues
- 6
DRAMP03479
Comments Information
Function
- Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
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Title
- A family of bacteria-regulated, cecropin D-like peptides from Manduca sexta.
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Pubmed ID
- 3143727
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Reference
- J Biol Chem. 1988 Dec 25;263(36):19424-19429.
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Author
- Dickinson L, Russell V, Dunn PE.