General Information

    • DRAMP ID

    • DRAMP03680

    • Peptide Name

    • Cathelicidin-3.4 (Bactenecin-3.4, Bac3.4; ChBac3.4; ruminant, animals)

    • Source

    • Capra hircus (Goat)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • Not found

    • Sequence

    • RFRLPFRRPPIRIHPPPFYPPFRRFL

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Swiss_Prot Entry P85170]Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa;
      • Gram-positive bacteria: Staphylococcus aureus, Listeria monocytogenes

    • Hemolytic Activity

      • [Swiss_Prot Entry P85170]Low hemolytic activity against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03680 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03680.

Physicochemical Information

    • Formula

    • C166H247N49O28

    • Absent Amino Acids

    • ACDEGKMNQSTVW

    • Common Amino Acids

    • P

    • Mass

    • 3377.1

    • PI

    • 12.4

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +8

    • Boman Index

    • -74.66

    • Hydrophobicity

    • -0.7

    • Aliphatic Index

    • 60

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 59.6

    • Polar Residues

    • 1

DRAMP03680

DRAMP03680 chydropathy plot

Comments Information

    • Function

    • Has low hemolytic activity towards human red blood cells.

Literature Information

  • ·Literature 1

    • Title

    • Unknown

    • Reference

    • Submitted (MAY-2007) to UniProtKB.

    • Author

    • Shamova O, Orlov D, Stegemann C, Lehrer RI, Brogden KA, Kolodkin N, Hoffmann R, Kokryakov VN.