General Information

    • DRAMP ID

    • DRAMP03703

    • Peptide Name

    • Mucroporin-like peptide (NDBP13; Arthropods, animals)

    • Source

    • Lychas mucronatus (Chinese swimming scorpion)

    • Family

    • Belongs to the short cationic antimicrobial peptide family

    • Gene

    • Not found

    • Sequence

    • LFFLPSLIGGLISAFK

    • Sequence Length

    • 16

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03703 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03703.

Physicochemical Information

    • Formula

    • C87H135N17O19

    • Absent Amino Acids

    • CDEHMNQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1723.13

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 29.8

    • Hydrophobicity

    • 1.656

    • Aliphatic Index

    • 152.5

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03703

Comments Information

    • Function

    • Cationic host defense peptide that have antibacterial activity by breaking membranes. Is more effective on Gram-positive than on Gram-negative bacteria (By similarity).

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.

    • Reference

    • BMC Genomics. 2010 Jul 28;11:452.

    • Author

    • Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L.