General Information

    • DRAMP ID

    • DRAMP03802

    • Peptide Name

    • Corticostatin 1 (Antiadrenocorticotropin peptide I; lagomorphs, mammals, animals)

    • Source

    • Oryctolagus cuniculus (Rabbit)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR

    • Sequence Length

    • 34

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03802 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03802.

Physicochemical Information

    • Formula

    • C163H265N63O44S6

    • Absent Amino Acids

    • DHKLMQTW

    • Common Amino Acids

    • R

    • Mass

    • 4003.65

    • PI

    • 10.2

    • Basic Residues

    • 9

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +8

    • Boman Index

    • -131.77

    • Hydrophobicity

    • -0.638

    • Aliphatic Index

    • 34.41

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 101.67

    • Polar Residues

    • 16

DRAMP03802

DRAMP03802 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production.

    • PTM

    • Problely contains three disulfide bonds 3-31; 5-20; 11-30.

Literature Information

  • ·Literature 1

    • Title

    • Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

    • Reference

    • J Biol Chem. 1985 Apr 25;260(8):4579-4584.

    • Author

    • Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.
  • ·Literature 2

    • Title

    • Isolation and structure of corticostatin peptides from rabbit fetal and adult lung.

    • Reference

    • Proc Natl Acad Sci U S A. 1988 Jan;85(2):592-596.

    • Author

    • Zhu QZ, Hu J, Mulay S, Esch F, Shimasaki S, Solomon S.
  • ·Literature 3

    • Title

    • Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptide

    • Reference

    • Endocrinology. 1992 Mar;130(3):1413-1423.

    • Author

    • Zhu Q, Solomon S.