General Information

    • DRAMP ID

    • DRAMP03836

    • Peptide Name

    • ETD135 (Mutant of ARD1; Heliomicin analogs)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFLNVNCWCET

    • Sequence Length

    • 44

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Candida albicans IHEM 8060 (MIC50=1.56 µg/ml), Candida albicans No.245962 (MIC50=1.56 µg/ml), Aspergillus fumigatus GASP4707 (MIC50=6.25 µg/ml), Cryptococcus neoformans A (MIC50=6.25 µg/ml), Fusarium solani FFUS 8591 (MIC50=1.56 µg/ml), Scedosporium prolificans FSSP 8591 (MIC50=0.2 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03836 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP03836.

Physicochemical Information

    • Formula

    • C205H312N62O63S6

    • Absent Amino Acids

    • MPQ

    • Common Amino Acids

    • CG

    • Mass

    • 4845.47

    • PI

    • 8.32

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -70.85

    • Hydrophobicity

    • -0.373

    • Aliphatic Index

    • 50.91

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 14355

    • Absorbance 280nm

    • 333.84

    • Polar Residues

    • 24

DRAMP03836

DRAMP03836 chydropathy plot

Comments Information

    • Function

    • Possess antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Lead optimization of antifungal peptides with 3D NMR structures analysis.

    • Reference

    • Protein Sci. 2004 Mar;13(3):703-713.

    • Author

    • Landon C, Barbault F, Legrain M, Menin L, Guenneugues M, Schott V, Vovelle F, Dimarcq JL.