General Information

    • DRAMP ID

    • DRAMP03921

    • Peptide Name

    • Cecropin A (1-8)-melittin (1-18)hybrid peptide

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KWKLFKKIGIGAVLKVLTTGLPALIS

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 µM), Pseudomonas aeruginosa OT97 (MIC=0.7 µM);
      • Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.4 µM), Bacillus megaterium Bm11 (MIC=0.4 µM), Staphylococcus aureus Cowan 1 (MIC=1 µM), Streptococcus pyogenes (MIC=2 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03921 helical wheel diagram
  • 1BH1-> 

    • Predicted Structure

Physicochemical Information

    • Formula

    • C136H232N32O30

    • Absent Amino Acids

    • CDEHMNQRY

    • Common Amino Acids

    • KL

    • Mass

    • 2795.53

    • PI

    • 10.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +5

    • Boman Index

    • 22.9

    • Hydrophobicity

    • 0.842

    • Aliphatic Index

    • 150

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 220

    • Polar Residues

    • 6

DRAMP03921

DRAMP03921 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.

    • Reference

    • FEBS Lett. 1992 Jan 20;296(2):190-194.

    • Author

    • Andreu D, Ubach J, Boman A, WÃ¥hlin B, Wade D, Merrifield RB, Boman HG.