General Information

    • DRAMP ID

    • DRAMP04046

    • Peptide Name

    • Immobilized peptide E23GIG magainin2

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SNMIEGVFAKGFKKASHLFKGIG

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;
      • Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.
      • Yeast: Candida albicans ATCC 10231.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04046 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04046.

Physicochemical Information

    • Formula

    • C114H180N30O29S

    • Absent Amino Acids

    • CDPQRTWY

    • Common Amino Acids

    • GK

    • Mass

    • 2466.93

    • PI

    • 10

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -9.64

    • Hydrophobicity

    • 0.083

    • Aliphatic Index

    • 72.17

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP04046

DRAMP04046 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.

    • Reference

    • Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.

    • Author

    • Haynie SL, Crum GA, Doele BA.